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Toth et al

Statements Data availability statement The original contributions presented in the study are included in the article/Supplementary Material, further inquiries can be directed to the corresponding author/s

Tissue-Level Interpretation Changes in body weight or adipose mass can result from altered food intake, hydration, lean mass, lipid synthesis, lipid mobilization, substrate oxidation, activity, thermogenesis, gastrointestinal effects, or tissue-specific adaptation

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They also regulate autophagy, which in turn regulates the immune system response [5]

A May 2025 study in Molecular Therapy from the INc-UAB showed that gene therapy increasing secreted klotho (s-KL) in mice extended lifespan by 15-20% while improving muscle, bone, and cognitive health at 24 months of age (equivalent to ~70 human years)