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Dermatological changes can also be seen due to alteration of the pigment mechanisms
however, in vivo, one could imagine that repeated 5FU exposures would drive selection of pre-existing niches of tumours cells that had higher mitochondrial functionality
Oxidized DNA fragments exit mitochondria via mPTP- and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling
PubMed PMID: 9849822
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