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Neurocritical care 35 (3), 862886

The results of several large randomized controlled trials indicated that maintaining blood glucose at near normal concentrations was the most important step in limiting the risk of diabetic neuropathy and lower extremity amputation (70-72)

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Once those receptors are fully occupied by one medication, adding another does not create more fullness or faster weight loss

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Clinical Pharmacokinetics, 57: 1529-1538