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Cause #3: Low Vitamin D Vitamin D is essential for RFC-mediated folate transportthe backup pathway that high-dose Leucovorin depends on
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Starting at lower doses and escalating gradually gives the body time to adapt without the full intensity of adjustment happening all at once
Furthermore, substance P augmented the expression of neuroprotective and anti-inflammatory genes in the ischemic brain, and induced neuronal survival in the brain penumbra
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