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In 2025, ongoing trials are evaluating whether MEK inhibition can delay or prevent malignant transformation, or serve as a neoadjuvant strategy to shrink MPNST prior to surgery (Gross et al., 2024)

A normally functioning Wnt signalling pathway ensures tissue regeneration and maintenance of tissue integrity, while deregulated Wnt plays a role in aging and cancer [ 12 ]

A major real-world study links GLP-1 receptor agonists to improved survival and lower recurrence risk in women with breast cancer, but researchers say clinical trials are needed before these drugs can be considered part of cancer care

Opinio Atual em Cardiologia, 23(3), 258-262.

To compare the effects of paraxanthine against caffeine and the impact of age, young 8-week-old (YOUNG) and aged 16-month-old (OLD) rats were evenly divided into four groups ( n = 8 per group): (i) vehicle control (CON), (ii) low-dose paraxanthine (PXN LOW), (iii) high-dose paraxanthine (PXN HIGH), and (iv) high-dose caffeine (CAF HIGH)

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