what are the disadvantages of oral semaglutide

what are the disadvantages of oral semaglutide Reduces HbA1c and Body Weight in Patients with Type 2 Diabetes Regardless Background Glucose-Lowering Medication: PIONEER Subgroup Analyses | Diabetes Therapy Novo Nordisk's Semaglutide lowers MACE

Name: what are the disadvantages of oral semaglutide Reduces HbA1c and Body Weight in Patients with Type 2 Diabetes Regardless Background Glucose-Lowering Medication: PIONEER Subgroup Analyses | Diabetes Therapy Novo Nordisk's Semaglutide lowers MACE
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A drug alone is not enough

This was disappointing after smaller studies suggested benefits where GLP-1 improved motor symptoms

induction of superoxide dismutase (SOD) for antioxidant protection

In the pathology of hydronephrosis, OS not only directly damages renal tubular cells but also activates inflammatory responses and fibrosis signaling pathways, further exacerbating renal tissue damage and fibrosis [12]