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People with ongoing, unexplained, or rapidly changing symptoms should obtain an in-person medical evaluation

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If patients tolerate topiramate well and require greater appetite or craving control, the dose may be increased to 50 mg twice daily or adjusted in smaller increments

Genetic mutations that inhibit MC4R signaling lead to hyperphagia, decreased energy expenditure, and early-onset obesity, highlighting the receptor's fundamental importance in metabolic control

Impaired adiponectin signaling contributes to disturbed catabolism of branched-chain amino acids in diabetic mice

Targeting the vulnerability to NAD(+) depletion in B-cell acute lymphoblastic leukemia