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Ruggiero R, Mascolo A, Spezzaferri A, Carpentieri C, Torella D, Sportiello L, et al

The majority of trial participants completed their protocols despite experiencing some GI symptoms

Metabolic Regulation: Activation of hypothalamic MC4R suppresses appetite (anorexigenic) and increases energy expenditure via sympathetic nervous system stimulation of brown fat thermogenesis

2010;50:S42-S49

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