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This novel class of medications currently yields one of the largest reductions in A1C [32]

El cido alfa-lipoico y la coenzima Q10 restauran la funcin mitocondrial y reducen la inflamacin oxidativa

1 GLP-1 RAs should be titrated until A1C goal, maximum dose, or patient tolerability has been met

No claims are made regarding therapeutic, diagnostic, or clinical applications

Starting weight loss therapy with uncontrolled hypothyroidism may: Confound assessment of treatment efficacy Complicate symptom attribution (fatigue, constipation overlap) Necessitate multiple medication adjustments simultaneously Practically speaking, patients may benefit from demonstrating stable thyroid function on consistent levothyroxine dosing before adding weight loss medications, though this is not a strict requirement

Importantly, GLP-1 medications also provide cardiovascular protection