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However, an 18.7% efficiency decline was observed between 24 and 120 h, which was attributed to synergistic factors: (1) arrhenius-driven thermal deactivation of LCC (E a = 58.2 kJmol 1 ) and (2) TPA-induced acidification (pH 1.8) causing non-competitive inhibition, as evidenced by 3.2-fold K m increase and 68% V max reduction

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John Furner, Walmart US CEO, observed, We definitely do see a slight change compared to the total population

Am J Physiol Gastrointest Liver Physiol