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More serious but rare concerns include acute pancreatitis (patients should be counselled to report severe, persistent abdominal pain radiating to the back) and gallbladder disease (including cholelithiasis and cholecystitis)

Gut and liver (2020) Chang CH, Tsai WC, et al

8 Clinically, oral melanoma is an asymptomatic, slow-growing, brown-to-black macule with irregular, asymmetric borders

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Vakov et al., 2023)

Wake up to skin that feels softer, smoother and firmer