[PMID: 1883342] PubMed record related to this compound for laboratory literature review
1.1 GLP-1 RAs: mechanisms and current medications GLP-1, an incretin hormone secreted by intestinal L-cells, plays a crucial role in postprandial metabolic homeostasis ( However, native GLP-1 is rapidly degraded by dipeptidyl peptidase-4 (DPP-4) ( 1.2 GLP-1 RAs and weight loss GLP-1 RAs exert weight-reduction effects by both slowing gut transit and directly activating anorexigenic neural circuits
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Assuming a preferential central action of GLP1/E, we conducted label-free, quantitative proteomic analyses in the hypothalamus of the two models of PCOS, after chronic treatment with the di-agonist, as a means to disclose putative pathways for the metabolic actions of the di-agonist, and the basis for the partially differential responses between the two models of PCOS, which diverge also in terms of phenotypic presentation