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not only found that LC3 protein expression was down-regulated in SCs in the HG environment, but also observed the appearance of morphologically and structurally abnormal autophagosomes in the cells, suggesting that autophagy is disrupted in SCs (86)

As GSH has a net negative charge at physiological pH, the high concentration of mGSH implies the existence of specific transport systems that work against an electrochemical gradient (Mari et al., 2009, 2010)

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Multicentre study on prevalence of endocrine complications in thalassaemia major

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68: 9324 Holme E, Jodal U, Linstedt S, et al