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Treated with GSK3 inhibitor LiCl, the expression levels of the phosphorylated GSK3 (Ser9) was significantly upregulated, Bax and cle-Caspase3 protein were found to be significantly downregulated, and that of Bcl-2 was significantly upregulated in Prx II-knockout HaCaT cells after H 2 O 2 treatment(Fig
Clinical studies have demonstrated that topical niacinamide improves the appearance of aging facial skin, including reductions in fine lines, wrinkles, yellowing, red blotchiness, and hyperpigmented spots, while also enhancing barrier function
Gut microbiota-derived metabolites, such as short-chain fatty acids (SCFAs), tryptophan metabolites, and immune stimulants, are likely mediators in this process [85]
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Pharmacokinetic parameters such as AUC, maximum plasma concentration (Cmax), terminal elimination t1/2, volume of distribution (Va), and clearance were calculated [2]
