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J Inherit.Metab Dis 9-10-2010

Drenthen et al used MRS to quantify occipital concentrations of glutamate and GABA in 33 adolescents, 15 with high-functioning autism (HFA) and 18 healthy controls

Absorption of exogenous L-carnitine Dietary L-carnitine The bioavailability of L-carnitine from food can vary depending on dietary composition

Pagan, F

Given that serotonin synthesis pathways are similar between the brain and periphery and across mammalian species, we here examine in humans the following hypotheses in both CFS and hypothyroidism with fatigue: (1) serum serotonin (S-5-HT) levels are low, (2) L-carnitine supplementation is associated with increased S-5-HT levels and reduced fatigue, and (3) there exists a correlation between peripheral S-5-HT and fatigue levels

Personalized Dosing Using a combination may allow a provider to use lower doses of each medication