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Treat adults with noncirrhotic metabolic dysfunction-associated steatohepatitis (MASH), previously called nonalcoholic steatohepatitis (NASH), with moderate to advanced liver fibrosis (stages F2 to F3)

2 Challenges of developing an oral peptide therapy The oral administration of peptides is not a new concept, and the challenges faced are best illustrated by considering the failure to date to produce a marketable oral formulation of insulin since its discovery in 1921 [1, 2, 8, 40]

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It differs from native IGF-1 at two positions: a 13-amino-acid N-terminal extension and substitution of arginine for glutamate at position 3

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and is expected to rise with an aging demographic and increasing prevalence of diabetes, the leading cause of CKD and kidney failure