Across human studies and reviews, adverse effects are uncommon at typical supplemental intakes, and when side effects do occur, they are usually mild and gastrointestinal in nature.12 13 44 A safety-focused review published in European Review for Medical and Pharmacological Sciences summarized available clinical and non-clinical data on myo-inositol and reported that only very high intake (around 12g per day) was consistently associated with side effects specifically mild gastrointestinal symptoms such as nausea, gas/flatulence, and diarrhea.44 The authors also noted that the severity of these effects did not increase with higher doses
Vegetarians and vegans are at a higher risk of developing vitamin B12 deficiency as they do not consume animal-based products, which are the primary sources of vitamin B12
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Therefore, the optimized B12 profile of Sample K not only contributes to nutritional adequacy but also supports athletic performance, recovery, and long-term health outcomes within plant-based dietary frameworks
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Wettergren A, Wojdemann M, and Holst JJ