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Strong target identification normally requires orthogonal evidence such as direct binding, receptor-specific functional assays, selective antagonism, genetic loss of function, rescue experiments, and biophysical or chemical target-engagement analysis

Dick P, Costa C, Fayolle K, et al

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Heart palpitations appear in some user reports, though less frequently than flushing

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This was proposed by an animal study investigating the potential of GHK-Cu on lipopolysaccharide-induced lung inflammation in mice