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Patients with Leber's Disease: Vitamin B12 levels may exacerbate optic nerve atrophy

PMID 30845641

While not toxic, excessively high doses are usually unnecessary

Our comprehensive injection of vitamin B12 complex offers insightful information

if neurological involvement is present, maintenance is every two months Oral therapy is generally not appropriate where absorption is impaired (e.g., pernicious anaemia), as adequate levels cannot be reliably achieved Because B12 is water-soluble and any excess beyond hepatic storage capacity is excreted in the urine, it has a low toxicity profile

Case reports describe telogen effluvium after B12 injections, resolving post-discontinuation