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This limitation became even more evident when patients approached end-stage disease and total knee arthroplasty (TKA)

Sierra-Rivera E, Summar ML, Dasouki M, Krishnamani MR, Phillips JA, Freeman ML: Assignment of the gene (GLCLC) that encodes the heavy subunit of gamma- glutamylcysteine synthetase to human chromosome 6

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However, long-chain fatty acids (those with 14 or more carbon atoms) cannot directly cross the inner mitochondrial membrane

Glucose disposal rate is a measure of how fast glucose is taken up by muscles once it has entered the bloodstream (3)