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Chronic cocaine exposure has been linked to an increased risk of Parkinsons disease, as it promotes -synuclein overexpression in dopamine neurons, causing resting tremors and neurotoxic damage (Mash et al., 2003)

Added to this are factors such as the chronic stress , the systemic inflammation and toxic load , which increase the need for micronutrients and further reduce their assimilation
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Yildirim, A., Gumus, M., Dalga, S., Sahin, Y

Notably, the hydroxyl group at the C4 position of the tetrahydropyran ring of substrate 7 also stabilizes the GSH-thiolate through an additional hydrogen bond (Extended Data Fig

Umrethia M, Ghosh PK, Majithya R, Murthy RSR (2007) 6-Mercaptopurine (6-MP) Entrapped Stealth Liposomes for Improvement of Leukemic Treatment without Hepatotoxicity and Nephrotoxicity

Its also possible that it interfere with chemotherapy treatments

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