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The role of s-nitrosylation and s-glutathionylation of protein disulphide isomerase in protein misfolding and neurodegeneration
Ufer C, Wang CC
Nature 594 , 594598 (2021)
When its depleted, everything from immune function to cognitive performance suffers
In both cases, stimulus concentrations may vary across several orders of magnitude imposing a great challenge for animals to reliably detect and follow stimulus changes (van As et al , 1985
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