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Several factors may explain this phenomenon, and it is important to recognize that persistent sugar cravings do not indicate treatment failure
End points The primary end points included the occurrence of solicited AEs during the supplementation period and unsolicited AEs within the 28 days following the start of supplementation
In STEP-1 (Wilding et al., NEJM 2021), 68 weeks of once-weekly 2.4 mg semaglutide plus lifestyle intervention produced a mean body-weight reduction of about 15%, versus about 2.4% with placebo a large, clinically meaningful, well-replicated effect
Like most medications that affect appetite and digestion, it can cause side effects, especially early on
Nature 640 , 534542 (2025)
More on this: Learn how semaglutide and phentermine compare
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