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Conventional therapies including physical therapy, rest, and anti-inflammatory medications form the standard care foundation
Since weight loss medications work systemically through receptor activation rather than requiring gallbladder function, the absence of this organ does not fundamentally impair their therapeutic mechanism
Nevertheless, current evidence supports GLP-1 RAs and multi-agonist formulations as highly promising pharmacotherapies that address the complex, multifactorial pathophysiology of MASLD while simultaneously improving cardiometabolic comorbidities, positioning them as cornerstone treatments in the evolving therapeutic landscape for this prevalent and burdensome disease
VA data are made freely available to researchers behind the VA firewall with an approved VA study protocol
however, some studies have shown a decrease in depressive symptoms for people on GLP-1 drugs
11 The REWIND CVOT trial reported worse ocular outcomes (requiring photocoagulation, anti-VEGF therapy, or vitrectomy) in patients treated with dulaglutide compared with placebo
