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This has also been addressed in our rewrite of some of the sections on dimer-based therapeutics, where we mention several poly-drug approaches
Trp53 fl/fl (AKP) mice 72 h post-tamoxifen intraperitoneal (i.p.) injection and cultured in 3D as previously reported (Extended Data Fig
Sci Immunol 7:eabm5505
The weight loss results proved impressive - 24-week trials showed average 10.6% weight loss at 1mg daily dose compared to 2% placebo, with some participants losing 15-20%
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