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Colchicine, Neomycin, Aminosalicylic Acid, H2-blockers (e.g., Ranitidine), and Proton Pump Inhibitors (PPIs, e.g., Omeprazole): These oral medications can all interfere with the intestinal absorption of dietary B12, making the need for injectable B12 more pronounced

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7 Despite the utility of this approach, SPS utilizes several organic solvents, including N,N-dimethylformamide (DMF), N-methyl-2-pyrrolidone, and dichloromethane, all of which are associated with toxic effects following exposure to humans and animals

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