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Individualizing Treatment Goals While weight reduction is a hallmark of GLP-1 therapy, the ideal target varies: Older adults may need more conservative dosing to prevent frailty Patients with polypharmacy or advanced CKD require closer monitoring Ethnicity, comorbidities and baseline weight all influence treatment strategy Personalization remains essential for balancing efficacy and safety

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Receptor tolerance is another: sustained GLP-1 stimulation can lead to partial desensitization, reducing the appetite-suppressing effect over time

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