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Randomized trials vs real-world evidence: how can both inform decision-making

These key studies clearly provided clinical proof-of-concept that blocking the catalytic activity of DPP-4 could be a viable approach to treat T2DM, whilst at the same time helped to allay concern over whether the metabolism of any other potential DPP-4 substrates might be affected to cause unwanted off-target effects

Many patients can transition from PPIs to H2 blockers, or from H2 blockers to occasional antacids, as their body fully acclimates

The path to recovery hinges on regular, daily supplementation of B12, spanning a minimum of three months to ensure the body has sufficient time to fully heal

Desires for specific foods can change depending on whether a person is generally hungry or full

Challenges: The key challenge for Sanofi is competition from more established and better marketed GLP-1 drugs, particularly those from Novo Nordisk and Eli Lilly