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S2) or phylogenetic diversity as measured by Faiths formula applied to the whole phylogenetic tree (Supplementary Fig

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The introduction of the R17 Cagri- E14 Cagri intra-peptide ionic lock energetically favours the formation of a predominant bypass conformation at the CTR, which, together with the P37 substitution and the effects induced by the N-terminal acylation, likely underlies its improved potency over rAmy at this receptor

While it can produce visible fairness, it comes with greater risk if done without medical supervision