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Tirzepatide is generally not appropriate for people who are pregnant, planning pregnancy, or breastfeeding, or for anyone with a personal or family history of medullary thyroid carcinoma or MEN 2

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Thus, NICE and ICER evaluations feed into international pricing strategies : Countries with cost-sensitive systems (like the UK, Nordic countries, Canada) will continue to push for discounted prices based on NICEs valuations ( [13] )

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