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In rats subjected to experimental hypoxia, a significant stress-mediated reduction in both the rate of phosphorylated respiration (V3, a 20% decrease) and the rate of ADP phosphorylation (ADP/t, a 31% decrease) was observed in brain mitochondria
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The peptides selective mechanism distinguishes it from broader-acting hormonal therapies with more complex side effect profiles
However, exclusive use of folic acid in treating vitamin B12 deficient megaloblastic anemia could result in progressive and irreversible neurologic damage
Periarticular subcutaneous injection offers a middle ground, delivering peptides near joint structures without requiring joint entry
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