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IGF1R autophosphorylation also recruits Shc, which leads to Grb2/SOS/Ras activation and downstream ERK1/2 phosphorylation
doi:10.1001/jamaoto.2019.0821
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We chose SGLT-2 inhibitors as the secondary comparator because they are also used at a disease stage similar to GLP-1 receptor agonists and have not been associated with the outcome.16 For both cohorts, we defined cohort entry as the date of the first prescription for either a GLP-1 receptor agonist or the comparator drug during the study period
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