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[5] The primary contraindication for hydroxocobalamin injection is a known hypersensitivity to hydroxocobalamin, cobalt, or any component of the formulation
Pregnant or breastfeeding women should avoid both compounds
Stage 2: Early Functional Deficiency Cellular B12 becomes insufficient
"Pernicious Anemia", StatPearls , Treasure Island (FL): StatPearls Publishing, PMID 31082033, retrieved July 15, 2025 "Vitamin B12 or folate deficiency anaemia Diagnosis"
Key Takeaways The standard initial dose for severe deficiency is 1,000 mcg intramuscularly daily or every other day
Regulators are concerned that making the medicine widely available could lead to: Misdiagnosis: Patients self-treating a different, underlying condition
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