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Possible drug interactions with Zoloft include: Nonsteroidal anti-inflammatory drugs (NSAIDs), including ibuprofen and aspirin Adderall (amphetamine/dextroamphetamine) Klonopin (clonazepam) Xanax (alprazolam) Drinking alcohol while taking sertraline may increase your risk of adverse effects, such as dizziness and drowsiness

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