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It was developed as a research compound under the code NNC 26-0161 and taken into a discontinued clinical study, so despite reaching human trials Ipamorelin holds no marketing authorisation in any jurisdiction

For instance, engineered IGF2 mutants with enhanced receptor affinity but abolished mitogenic signaling have been developed to outcompete endogenous ligands [105]

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Its low molecular weight (~340 Da) means it reaches tissue compartments that larger peptides may not, and its stability profile is well-suited to combination formulations

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