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Two features of the design are worth understanding because they explain the molecules behavior: D-amino acids confer stability

Furthermore, I/R can disrupt endothelial glycocalyx integrity and transiently increase glomerular permeability, thereby enhancing nanoparticle passage across the GFB [52, 53]

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Josefson JL, Catalano PM, Lowe WL, Scholtens DM, Kuang A, Dyer AR, et al

This regulatory network is illustrated in Fig