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Glutamatergic metabolite correlations with neuropsychological tests in first episode schizophrenia

Our findings align with previous observational studies on GLP-1 RAs, which generally report no significant association between these medications and increased suicide risk ( The psychiatric safety observed in our study is consistent with findings from major RCTs involving tirzepatide, such as the SURMOUNT trials ( The reduction in suicidal ideation and attempts observed in patients treated with tirzepatide could be explained by several biological mechanisms

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Originally developed for diabetes management, these therapies have demonstrated significant effectiveness in weight management and are reshaping conversations around obesity treatment, chronic disease prevention, and long-term healthcare costs

However, there have been reports of bronchitis and upper respiratory tract infections in people taking semaglutide