North America dominated the market share by 64% in 2025
Injections tend to cost more upfront due to higher doses, supplies, and sometimes provider involvement
Given the recent results of the CREDENCE trial, many patients will also be treated with an SGLT2-inhibitor, allowing the trial to study the combined use of these agents on renal outcomes
As consequences of polymorphism of MTHFR , reduction of MTHFR enzymatic activity would cause impaired methylation as well as deficiency of folate
This can lead to reduced calorie intake and, over time, significant weight loss
Significant weight regain was observed in both subgroups (WMD = 1.45 kg, 95% CI 0.62 to 2.28, P = 0.006, I 2 = 72%