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Evidence from randomized controlled trials suggests that OA-related knee pain and function improve with semaglutide but not with liraglutide treatment, and observational studies suggest that GLP-1RA use reduces the risk of surgery for knee OA

Experimental studies have uncovered numerous benefits of GLP-1 RAs on SM

Fahey et al

Corsini EM, Mitchell KG, Hofstetter WL, Mehran RJ, Roth JA, Sepesi B, Swisher SG , Vaporciyan AA, Walsh GL, Antonoff MB, Rice DC

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