In cardiomyocytes, ROS activate ERK/p38 MAPK pathways to mediate hypertrophy and induce apoptosis via JNK/p53 pathways and mitochondrial membrane permeability alterations [323, 324]
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Notably, oxidative stress-a well-established inducer of ferroptosis-has also been recognized as a critical driver of AD pathology [118]
However, it is crucial for our patients to understand that BPC-157 is not approved by the FDA for human use, and its safety and efficacy have not been fully established in clinical trials