Since suboptimal Se levels have been reported in inducing oxidative stress, supplementation with trace elements, including Se, copper, and zinc, revealed beneficial effects on the improvement of infection following major burns [64]
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In the fox-odor container test, 3xTg mice exhibit increased predator odor-induced anxiety, which is detectable at 2 months of age (i.e., before the onset of AD pathology) and is more pronounced in aged females than males (Szab et al., 2023)
Moreover, using probucol (500 mg/day, P.O for 6 months) for secondary prevention in patients with CHD lowered the incidence of the patients primary endpoint (cardiovascular disease death, hospitalization rate), which may be partly due to its strong antioxidant capacity [245]
The objective of the current study was to demonstrate the therapeutic potential of oral administration of glutathione in an open-label, single-arm, multicenter, pilot study prior to subsequent large-scale clinical trials
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