Chronic unpredictable stress, considered a model of depression, results in a reduction in dendritic lengths and branching of apical dendrites, the loss of functional synaptic spines, and the reduction of dendritic complexity in PFC neurons and in the hippocampal CA3 pyramidal neuronal cell layer (McEwen et al., 2012
The other reason, I've responded yes to Game Changer is that, that trial heralded in a new direction for the treatment of obesity, and that is harnessing our intestinal hormones, which we talked about a little bit early
Manufacturers have invested heavily in new peptide production facilities and outsourcing the manufacture to various CDMOs
Every single one comes with side effects, potential complications, or long term consequences
The GI disruption is not a flaw in the design it is the design, operating at pharmacological doses
It also cleans up wound-related debris, which helps your body heal after an injury