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Stopping treatment can be followed by weight regain

The effect of broccoli glucoraphanin supplementation on ameliorating high-fat-diet-induced obesity through the gut microbiome and metabolome interface

doi: 10.1016/j.arr.2024.102274

Glucagon receptor agonism increases hepatic glucose output and is hypothesised to promote lipolysis and increase energy expenditure, though the magnitude of this effect in humans is uncertain and context-dependent