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In addition to fatigue, a deficiency of B12 can lead to other symptoms like pale skin, headaches, depression, gastrointestinal problems, difficulty concentrating, decreased mental function, mouth and tongue pain or inflammation, and paresthesia in your hands and feet

These findings suggest that administering hepsin can effectively regulate GJ expression in wild-type mice, highlighting its potential as a therapeutic target to protect against APAP-induced hepatotoxicity, potentially in human patients