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Nat Commun 2017

NAD+ does more than produce energy - it acts as a co-substrate for enzymes such as sirtuins and PARPs that maintain DNA repair and genomic stability

Combined with the molecular weight argument (semaglutide is too large to easily cross biological barriers into milk) and the poor oral bioavailability (any swallowed semaglutide would be destroyed in the infant gut), the safety profile looks reassuring

It could be due to a formulary change, a need for prior authorization, or even an error

Dulai, G

In MV4-11 cells, pro-caspase-8, -9, and -3 levels were reduced by 7.1-, 50.0-, and 3.6-fold, respectively, after 3 h compared with DMSO-treated controls (Fig