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Spironolactone handles the hormonal cosmetic symptoms, while semaglutide targets the underlying metabolic dysfunction

To qualify, individuals typically need to have type 2 diabetes

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54 NietzelT.MostertzJ.RubertiC.NeG.FuchsP.WagnerS.et al (2020)

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Mounjaro came first and is FDA-approved : To treat type 2 diabetes in adults by controlling their blood sugar levels Zepbound is FDA-approved : For chronic weight management in adults with obesity or overweight and a weight-related medical condition To treat obstructive sleep apnea in adults with obesity Prior to Zepbounds approval, healthcare providers may have been more likely to prescribe Mounjaro off-label for weight loss to patients with overweight or obesity who may not have had type 2 diabetes