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Sex hormone changes during weight loss and maintenance in overweight and obese postmenopausal African-American and non-African-American women
The studys main findings were that compared to placebo: Semaglutide lowered the relative risk of a non-fatal heart attack by 26% It also lowered the relative risk of a stroke by 39% And lowered the relative risk of a major cardiovascular event by 26% This sounds significant
To mask study drug, semaglutide or placebo (saline) in sterile amber glass vials were given to participants, along with insulin syringes, dispensed by the research pharmacy, who were unblinded to drug allocation
These animals showed a similar pattern, with high GLP-1 levels that failed to properly regulate blood sugar, consistent with GLP-1 resistance
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