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Efficacy and safety of once-weekly semaglutide versus once-daily insulin glargine as add-on to metformin (with or without sulfonylureas) in insulin-naive patients with type 2 diabetes (SUSTAIN 4): a randomised, open-label, parallel-group, multicentre, multinational, phase 3a trial

First, context matters enormously

Animal studies suggest GLP-1 drugs may increase synaptic plasticity, the process by which the brain rewires its connections

Key Components

Ammonia readily crosses the blood-brain barrier and is thought to inhibit glutamate uptake, thereby increasing extracellular glutamate concentrations in the brain and resulting in activation of NMDA receptors

First, taking straight glutathione orally is not that effective because it doesnt make it past the digestive tract into the bloodstream