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Indeed, patients are required to have measurable low antiviral Ab titers to qualify for both treatment with approved gene therapy products such as Zolgensma and for inclusion in clinical trials [358, 359]
Furthermore, there are diverse pathways leading to the resistance to IGF-IR-targeted therapy
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They noted the findings were consistent across several subgroups and in sensitivity analyses
Wegovy is now uniquely positioned as the first and only GLP-1 treatment approved for MASH, complementing the already proven weight loss, cardiovascular benefits and extensive body of evidence linked to semaglutide, said Martin Holst Lange, executive vice president, chief scientific officer and head of Research and Development, at Novo Nordisk
The findings do need to be confirmed in randomized controlled trials
