Deficiency Causes Although folate deficiency is uncommon in the United States, it is estimated to be more prevalent worldwide (11)
The mechanistic plausibility is strong (NNMT inhibition increases NAD+ without the gastrointestinal side effects of high-dose nicotinamide), and the short-term tolerability profile is excellent, but we mean this sincerely: if you're using this compound for durations beyond what the published trials covered, you are operating in uncharted territory
The answer is often yes, because the dual-receptor action provides a different, and often stronger, metabolic response
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"The effects of L-carnitine supplementation on glycemic control: a systematic review and meta-analysis of randomized controlled trials." National Library of Medicine
If you take one of these medications, which include lithium, valproate (Depakote), and lamotrigine (Lamictal XR), you can ask your prescriber to order labs so you can get a baseline